All the SteinerBio formulations out-performed both the control (no graft) and nearly doubled the bone production of the allograft sites. When using a control as a baseline, these findings show that SteinerBio bone grafts stimulate bone growth and allografts inhibit bone growth. The three graphs on inflammation show that SteinerBio produced less inflammation than the controls and the inflammation produced by allografts are dramatic. The final chart shows that allografts produce the largest amount of fibrosis. This study confirms the safety and effectiveness of SteinerBio graft materials and the superiority of SteinerBio science-based bone grafts over allografts.
There have been many animal and human studies that have compared cadaver bone grafts to science-based (synthetic) bone grafts and there has never been a study published where any type of cadaver bone graft has outperformed synthetics. There are publications that found synthetics outperformed cadaver bone grafts (references upon request).
While synthetics have been found to outperform allografts, these synthetics were developed decades ago and as science always improves, cadaver bone grafts never improve. This is the first study comparing a modern science-based bone graft to allografts, and the superiority of a modern science-based bone graft is clearly evident.
Anyone who knows anything about bone knows that normal bone cannot form in the presence of chronic inflammation as in periodontal disease, osteoporosis, and osteoarthritis. However, in these diseases the agent that causes the resorption are cytokines (molecules) produced distant from the bone. The inflammatory cell infiltrate that is producing the cytokines are not in the bone. Osteoarthritis is most like allografts in the type of bone formed. The inflammatory infiltrate is in the synovial fluid and is made up primarily of lymphocytes, resulting in sclerotic bone formation that can end with total knee replacement. However, with allografts the lymphocyte infiltration is actually in the bone and on the bone that is forming, yet our profession somehow thinks that this will produce normal bone. The only excuse the profession has is that no one in the profession has seen histology of allografts mineralizing. The following histology is bone mineralization of a site grafted with a mineralized freeze dried bone allograft from the study:
